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About Z-Scores (in general)

According to the American Society of Echo's Guidelines and Standards for Performance of a Pediatric Echocardiogram:

In addition to reporting the absolute values, it is useful to report quantitative measures within the context of age- or size-appropriate norms (eg, z-score values).

A z-score indicates:
how many standard deviations an observation is above or below the mean. It allows comparison of observations from different normal distributions, which is done frequently in research.
(See the Wikipedia entry for more information about z-scores.)Concerning the application of z-scores to pediatric cardiology, interested persons should read:


About Me

My name is Dan Dyar. Among many other things, I am a Pediatric Cardiac Sonographer. Having worked in this field since Before The Internet, I sometimes observe the collision of technology and information in this field and am astonished by the disparity: we are simultaneously incredibly advanced and desperately primitive.
I hope this website helps soften these collision.
Should you wish to contact me, fill out the form here and hope for the best.

Disclaimer

The calculators provided are not meant to be a substitute for professional advice and are not to be used for medical diagnosis. All calculations must be confirmed before clinical use or diagnostic purposes by qualified medical professionals. The author makes no claims of the accuracy of the information contained herein. The authors make no claims whatsoever, expressed or implied, about the authenticity, accuracy, reliability, completeness or timeliness of the material, software, text, graphics and links given. In no event shall the author, suppliers, affiliates or any third parties be liable in any manner whatsoever for any damage arising upon use of any information provided.
THE INFORMATION, SOFTWARE, PRODUCTS, AND SERVICES INCLUDED IN OR AVAILABLE THROUGH THE WEB SITE MAY INCLUDE INACCURACIES OR TYPOGRAPHICAL ERRORS. CHANGES ARE PERIODICALLY ADDED TO THE INFORMATION HEREIN. CHANGES IN THE WEB SITE MAY BE MADE AT ANY TIME. ADVICE RECEIVED VIA THE WEB SITE SHOULD NOT BE RELIED UPON FOR PERSONAL, MEDICAL, LEGAL OR FINANCIAL DECISIONS AND YOU SHOULD CONSULT AN APPROPRIATE PROFESSIONAL FOR SPECIFIC ADVICE TAILORED TO YOUR SITUATION. IF YOU ARE DISSATISFIED WITH ANY PORTION OF THE WEB SITE, OR WITH ANY OF THESE TERMS OF USE, YOUR SOLE AND EXCLUSIVE REMEDY IS TO DISCONTINUE USING THE WEB SITE.

Comments (113)

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mariela ingber's avatar

mariela ingber · 804 weeks ago

I would like to know in what view do you obtain the measurement for the RVID(d). Is it in the parasternal long axis or short axis views. Normally I obtain it from the parasternal short axis and they seem to be with an abnormal Z-score.

Thanks
1 reply · active less than 1 minute ago
Hi Dan
Sri Rao here. Thanks for putting this together, I use these tools very often.
Any chance it can be converted into an App for the iPhone? Might be asking for a lot but thought I'd give it a shot! Take care
Hello Sri,

I am glad to hear that you are getting good use out of the site.

I get lots of request for a ParameterZ iPhone App. The problem from my end is that the entry point is kinda steep: I don't have a Mac or an iPhone to develop this on. The ROI if I fund this myself doesn't look reasonable.

Perhaps I should make this into a campaign.
Gerald Hanson's avatar

Gerald Hanson · 769 weeks ago

What are the chances of seeing this on Android?
Google code means nothing to me but - does that make this easier to do than iPhone?
1 reply · active 769 weeks ago
Kjetil Lenes's avatar

Kjetil Lenes · 739 weeks ago

Very nice! As to Android/IPhone Apps: Several of those publications are quite easily adapted to an Excel Spreadsheet
4 replies · active 737 weeks ago
do you have the actual formula for all the calculations for this one... gonna use it for a requirement in school... we are only allowed to manually calculate it.... please help and thank you....
Dear Dan,

Get in touch with me at ramya.shankar@philips.com ... I am quite keen on discussing the conversion of this concept into an iphone app ..

Regards,
Ramya
What about RVEDV z scores?
1 reply · active 676 weeks ago
Have you ever considered posting pediatric MRI published reference values for cardiac structures/volumes/etc? They are even harder to find than echo reference values, but there are several papers out there, and they still keep coming.
Sam:

I have indeed. See cmr.parameterz.com. That site requires you to sign in with a Google/gmail account.
Dr. Martin Lewin's avatar

Dr. Martin Lewin · 666 weeks ago

Hi Dan,
do you think you could extend the TAPSE section?
Koestenberger et al., Neonatology 2011;100:85-92:
Systolic Right Ventricular Function in Preterm and Term Neonates: Reference Values of the Tricuspid Annular Plane Systolic Excursioin (TAPSE) in 258 Patients and Calculation of Z-Score Values.
Regards Martin, Germany
1 reply · active 666 weeks ago
Hello Dan,

Thank you for your great service.

I'm wondering why you don't have, complete, Boston Children Echo z-scores. The way you have for Detroit & Wessex...

Thanks.
2 replies · active 653 weeks ago
Should we expect to see Doppler and TDI values here soon?
1 reply · active 620 weeks ago
Quick question: is it possible to have an option to enter the BSA directly please on your Z-score calculators? In my work we are sometimes reviewing cardiologists' or sonographers' measurements, and they occasionally quote the BSA but do not say the height and weight they used for their calculation (or which formula they used). Thanks.
1 reply · active 599 weeks ago
hi Dan
I wonder, is it too early to include MAPSE (Koestenberger AHJ 2012) reference into your wonderful database? Just a suggestion ...
2 replies · active 599 weeks ago
What Z value is considered to degree the enlargement and the hypoplasie as discrete, moderate or severe?
Excellent question.

The classification of disease based on echo measurement z-scores is something of a Holy Grail for pediatric cardiology. There is a paucity of research that associates outcome with z-scores.

You might find these articles interesting though:

* Distribution and Categorization of Echocardiographic Measurements in Relation to Reference Limits [http://circ.ahajournals.org/content/96/6/1863.full]

* Improved classification of coronary artery abnormalities based only on coronary artery z-scores after Kawasaki disease. [http://www.ncbi.nlm.nih.gov/pubmed/20024653]

* Reference values for echocardiographic measurements in urban and rural populations of differing ethnicity: the Strong Heart Study. [http://www.ncbi.nlm.nih.gov/pubmed/11391289]

I also pondered this very subject myself a while back: http://fortuitousconcatenation.blogspot.com/2008/...
Uriel Katz's avatar

Uriel Katz · 540 weeks ago

Hi Dan,
This is a great site and extremely useful!
Occasionaly I use different scores for the same child (i.e. aortic root and ventricular dimentions or M-mode and 2D). Is itt possible to be able to enter the childs weight and height once , say at the top, and then have it automatically all over the site?
Thanks,
Uri
1 reply · active 540 weeks ago
Lizabeth Lassiter's avatar

Lizabeth Lassiter · 518 weeks ago

Nice post!
Lizabeth Lassiter's avatar

Lizabeth Lassiter · 518 weeks ago

Setting of a pediatric echo lab may require various types of calculations and that work must be done by expert to avoid mistakes. Pediatric professionals should handle that work. pediatric fellowships
Excellent article you have shared thanks for sharing .I appreciated of you.
Great post... Thanks for sharing the best informative post..
M THINAKAR VEL's avatar

M THINAKAR VEL · 468 weeks ago

Dear Dan, thank you very much for your great work. You made our life very easy to calculate Zscores. I am Dr. Thinakar Vel, Paediatric cardiologist from Kuwait. We have done one research on to estimate normal reference ranges in preterm infants. We used your calculator for Zscores. Very useful. We are going to publish the article. We would like to include your name in references. Please send your full details. Kindly send your article details which states Zscore calculator. Thanking you.
Michael Silberbach's avatar

Michael Silberbach · 466 weeks ago

Where is the Quezad et al Z-score calculator for Turner syndrome ?
Tha BSA-adjusted z-scores for the aortic valve, aortic root, and aortic arch — developed specifically for Turner syndrome patients — can be found only on the main site: http://www.parameterz.com/refs/quezada-ajmg-2015

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